Biofilm-Forming Staphylococcus epidermidis Expressing Vancomycin Resistance Early after Adhesion to a Metal Surface

Figure 2

Changes in BCR with changes in the VCM concentration administered at various time points of biofilm formation. In the immediate group, BCR after 20-hour culture was 98% or higher when the VCM concentration was 2 μg/mL or lower (a). BCR significantly decreased when the VCM concentration was 4 μg/mL or higher　(a). In the 2 hr group, BCR was 98% or higher when the VCM concentration was 4 μg/mL or lower. BCR significantly decreased to 78.8% at 8 μg/mL (b). In the 4 hr group, BCR was 98% or higher when the VCM concentration was 8 μg/mL or lower, it significantly decreased to 59.1% at 16 μg/mL, and it was mostly constant at 32 μg/mL or higher (53.9–49.8%) (c). In the 8 hr group, BCR was 96% or higher when the VCM concentration was 64 μg/mL or lower, it significantly decreased to 94.8% at 128 μg/mL, and it was mostly constant at 256 μg/mL or higher (94.9–93.4%) (d). Values represent mean and error bars indicate SD (). versus control.

(a)

(b)

(c)

(d)