The Biocompatibility of Degradable Magnesium Interference Screws: An Experimental Study with Sheep

Figure 5

Location of multiple macrophages. High amounts of multiple macrophages (arrow) were found in the surrounding of Mg implants (A)–(E) 6 and (F)–(H) 12 weeks (w) and (I)–(L) 1 year (y) after implantation. Multiple macrophages were identified by (A, B, and E) their size and multiple nuclei (HE staining) as well as by (C)-(D), (I)-(J) TRAP and (F)-(G), (K)-(L) CD68 labeling. They were situated at the surface of gas voids (gb), bone (b), and Mg corrosion product (cp) as well as in the granulation tissue (gt) surrounding the gas voids. Imp: empty space that was created by removing the implant before preparation of paraffin sections. Square: detail shown in higher magnification in subsequent picture, and v: vessels. Inset in (A) overview of A. Inset in (H) higher magnification of TRAP positive cells at the corrosion product.