Transcriptional Changes Associated with Long-Term Left Ventricle Volume Overload in Rats: Impact on Enzymes Related to Myocardial Energy Metabolism
Table 5
Downregulated genes in the category “mitochondrion” from the GO cellular component in 9-month LVs from severe volume overload compared to age-matched sham-operated animals.
Target ID
Definition
Fold change
value
CYP11A1
Cytochrome P450, family 11, subfamily a, polypeptide 1
0,482
0.00057
ECH1
Enoyl-Coenzyme A hydratase 1, peroxisomal
0,497
0.00039
HADHA
Hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit
0,517
0.00030
DECR1
2,4-Dienoyl CoA reductase 1, mitochondrial
0,519
0.00343
ACAA2
Acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)