Review Article
The G Allele of CaSR R990G Polymorphism Increases Susceptibility to Urolithiasis and Hypercalciuria: Evidences from a Comprehensive Meta-Analysis
Table 1
Characteristics of studies included in the meta-analysis for associations between CaSR polymorphisms and urolithiasis risk.
| CaSR A986S polymorphism | Case () | Control () | HWE | Year | Author | Ethnicity | Country | Genotyping | SOC | Subjects | A/A | A/S | S/S | A/A | A/S | S/S |
| 2013 |
Han et al. [15] | Asian | China | Sequencing | PB | PHPT and healthy | 64 | 5 | 1 | 215 | 15 | 0 | Y | 2013 | Han et al. [15] | Asian | China | Sequencing | HB | PHPT patients | 64 | 5 | 1 | 88 | 6 | 0 | Y | 2011 | Kim et al. [5] | Asian | Korea | PCR | PB | Healthy population | 415 | 18 | 0 | 191 | 6 | 0 | Y | 2010 | Shakhssalim et al. [13] | Asian | Iran | Sequencing | PB | Healthy population | 71 | 26 | 2 | 93 | 14 | 0 | Y | 2009 | Hamilton et al. [16] | Caucasian | Canada | Sequencing | PB | Healthy population | 157 | 56 | 10 | 469 | 191 | 16 | Y | 2007 | Scillitani et al. [17] | Caucasian | Canada | Sequencing | PB | PHPT and healthy | 78 | 36 | 7 | 282 | 130 | 20 | Y | 2007 | Scillitani et al. [17] | Caucasian | Canada | Sequencing | HB | PHPT patients | 78 | 36 | 7 | 52 | 38 | 14 | Y | 2006 | Corbetta et al. [18] | Caucasian | Italy | Taqman | HB | PHPT and healthy | 30 | 12 | 1 | 91 | 42 | 4 | Y | 2006 | Corbetta et al. [18] | Caucasian | Italy | Taqman | HB | PHPT patients | 30 | 12 | 1 | 24 | 14 | 6 | Y | 2002 | Vezzoli et al. [14] | Caucasian | Italy | Sequencing | PB | Healthy population | 157 | 74 | 57 | 44 | / |
| CaSR R990G polymorphism | Case () | Control () | HWE | Year | Author | Ethnicity | Country | Genotyping | SOC | Subjects | R/R | R/G | G/G | R/R | R/G | G/G |
| 2013 | Han et al. [15] | Asian | China | Sequencing | PB | PHPT and healthy | 20 | 40 | 10 | 50 | 119 | 61 | Y | 2013 | Han et al. [15] | Asian | China | Sequencing | HB | PHPT patients | 20 | 40 | 10 | 24 | 53 | 17 | Y | 2010 | Shakhssalim et al. [13] | Asian | Iran | Sequencing | PB | Healthy population | 87 | 10 | 2 | 105 | 2 | 0 | Y | 2009 | Hamilton et al. [16] | Caucasian | Canada | Sequencing | PB | Healthy population | 171 | 38 | 14 | 568 | 102 | 6 | Y | 2007 | Scillitani et al. [17] | Caucasian | Canada | Sequencing | PB | PHPT and healthy | 105 | 16 | 0 | 391 | 41 | 0 | Y | 2007 | Scillitani et al. [17] | Caucasian | Canada | Sequencing | HB | PHPT patients | 105 | 16 | 0 | 102 | 2 | 0 | Y | 2006 | Corbetta et al. [18] | Caucasian | Italy | Taqman | HB | PHPT and healthy | 34 | 9 | 128 | 9 | / | 2006 | Corbetta et al. [18] | Caucasian | Italy | Taqman | HB | PHPT patients | 34 | 9 | 43 | 1 | / | 2002 | Vezzoli et al. [14] | Caucasian | Italy | Sequencing | PB | Healthy population | 216 | 15 | 100 | 1 | / |
| CaSR Q1011E polymorphism | Case () | Control () | HWE | Year | Author | Ethnicity | Country | Genotyping | SOC | Subjects | Q/Q | Q/E | E/E | Q/Q | Q/E | E/E |
| 2010 | Shakhssalim et al. [13] | Asian | Iran | Sequencing | PB | Healthy population | 94 | 5 | 0 | 107 | 0 | 0 | Y | 2007 | Scillitani et al. [17] | Caucasian | Canada | Sequencing | PB | PHPT and healthy | 113 | 8 | 0 | 402 | 30 | 0 | Y | 2007 | Scillitani et al. [17] | Caucasian | Canada | Sequencing | HB | PHPT patients | 113 | 8 | 0 | 102 | 2 | 0 | Y | 2002 | Vezzoli et al. [14] | Caucasian | Italy | Sequencing | PB | Healthy population | 222 | 9 | 0 | 98 | 3 | 0 | Y |
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PB: Population-based study, HB: hospital-based study, and HWE: Hardy-Weinberg equilibrium.
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