Review Article
The G Allele of CaSR R990G Polymorphism Increases Susceptibility to Urolithiasis and Hypercalciuria: Evidences from a Comprehensive Meta-Analysis
Table 2
Characteristics of individual studies included in the meta-analysis of CaSR polymorphisms and urine calcium concentration.
| CaSR A986S polymorphism | Author | Year | Ethnicity | Country | Sample size | Subjects | AA | Mean | SD | AS + SS | Mean | SD |
| Han et al. [15] | 2013 | Asian | China | 164 | PHPT patients | 151 | 413.47 | 204.96 | 13 | 506.05 | 180.5 | Kim et al. [5] | 2011 | Asian | Korea | 433 | urolithiasis patients | 415 | 190.3 | 112 | 18 | 138.6 | 84 | Ferreira et al. [19] | 2010 | Mixed | Brazil | 187 | urolithiasis patients | 177 | 239 | 100 | 10 | 280 | 86 | Vezzoli et al. [20] | 2007 | Caucasian | Italy | 243 | Females | 168 | 6.01 | 0.233 | 75 | 5.72 | 0.323 |
Pérez-Castrillón et al. [21] | 2006 | Caucasian | Spain | 48 | osteoporotic women | 33 | 219 | 124 | 15 | 175 | 175 | Corbetta et al. [18] | 2006 | Caucasian | Italy | 79 | PHPT patients | 51 | 6.76 | 3.93 | 28 | 7.61 | 4.27 | Harding et al. [22] | 2006 | Caucasian | England | 188 | dizygotic female twin pairs | 141 | 0.44 | 0.15 | 47 | 0.46 | 0.18 | Kelly et al. [23] | 2006 | Caucasian | England | 121 | Healthy populations | 90 | 0.2 | 0.09 | 31 | 0.19 | 0.1 | Vezzoli et al. [14] | 2002 | Caucasian | Italy | 207 | urolithiasis patients | 133 | 6.91 | 0.26 | 74 | 7.96 | 0.46 |
| CaSR R990G polymorphism | Author | Year | Ethnicity | Country | Sample size | Subjects | RR | Mean | SD | RG + GG | Mean | SD |
| Corbetta et al. [18] | 2006 | Caucasian | Italy | 79 | PHPT patients | 69 | 6.77 | 4.31 | 10 | 9.05 | 2.05 | Harding et al. [22] | 2006 | Caucasian | England | 188 | Dizygotic female twin pairs | 167 | 0.45 | 0.17 | 21 | 0.4 | 0.42 | Vezzoli et al. [14] | 2002 | Caucasian | Italy | 148 | Urolithiasis patients | 133 | 6.91 | 0.26 | 15 | 9.68 | 0.87 | Shakhssalim et al. [13] | 2010 | Asian | Iran | 206 | Urolithiasis and healthy | 192 | 187.06 | 99.75 | 14 | 214.43 | 99.23 | Ferreira et al. [19] | 2010 | Mixed | Brazil | 185 | Urolithiasis patients | 177 | 239 | 100 | 8 | 283 | 112 | Vezzoli et al. [20] | 2007 | Caucasian | Italy | 243 | Females | 220 | 5.82 | 0.196 | 23 | 7.59 | 0.63 |
| CaSR Q1011E polymorphism | Author | Year | Ethnicity | Country | Sample size | Subjects | QQ | Mean | SD | QE + EE | Mean | SD |
| Vezzoli et al. [20] | 2007 | Caucasian | Italy | 243 | Females | 230 | 6.03 | 0.193 | 13 | 5.2 | 0.966 | Harding et al. [22] | 2006 | Caucasian | England | 188 | Dizygotic female twin pairs | 172 | 0.45 | 0.14 | 16 | 0.37 | 0.62 | Vezzoli et al. [14] | 2002 | Caucasian | Italy | 142 | Urolithiasis patients | 133 | 6.91 | 0.26 | 9 | 6 | 0.91 | Shakhssalim et al. [13] | 2010 | Asian | Iran | 206 | Urolithiasis and healthy | 201 | 233.6 | 139.9 | 5 | 187.81 | 98.73 | Ferreira et al. [19] | 2010 | Mixed | Brazil | 185 | Urolithiasis patients | 177 | 239 | 100 | 4 | 287 | 80 |
|
|