Review Article

Polysaccharide-Coated Magnetic Nanoparticles for Imaging and Gene Therapy

Table 2

Various strategies used for polysaccharide-coated MNPs that have been used for imaging.

PolysaccharideModificationIn vitro/in vivo Reference

AlginateAlginate-poly-L-lysine-alginate (APA)C2C12 myoblast cell line
implanted into the abdominal cavity of mice
[61]

ChitosanChlorotoxin (CTX),
Polyethylene glycol (PEG)
Near-IR fluorophore (NIRF), Cy.5.5
Brain
Autochthonous medulloblastomas in genetically engineered ND2: SmoA1 mice
[62]

DextranFITC-derivatized Tat peptide
Chelator DTPA
Hematopoietic and neural progenitor cells[63]

Hyaluronic acidDopamineHCT116
NIH3T3 cells
[64]

HeparinGold-deposited
Glycol chitosan
Pluronic F-68
Tumor-bearing mice, SCC-7 (squamous cell carcinoma) cells were induced in male C3H/HeN mice by subcutaneous injection[65]

MannanCarboxylicSubcutaneous injection in a rat model[66]

Pullulanā€‰L929 cells
KB cells with hyperthermic effect
[67]

StarchPoly(ethylene glycol) (PEG)Male Fisher 344 rats bearing 9L-glioma brain tumors[68]