BioMed Research International / 2015 / Article / Tab 3 / Review Article
Polysaccharide-Coated Magnetic Nanoparticles for Imaging and Gene Therapy Table 3 Strategies for polysaccharide coating MNPs for gene delivery.
Polysaccharide Modification Gene In vitro /in vivo Reference Chitosan Polyethylenimine (PEI) Poly(ethylene glycol) (PEG) Enhanced green fluorescent protein (EGFP) plasmid DNA C6 cells Xenograft C6 tumors [69 ] Chitosan Hexanoyl chloride-modified Viral gene (Ad/LacZ) K562 cells intestine and lung of balb-c mice [70 ] Chitosan Poly(ethylene glycol) (PEG) Enhanced green fluorescent protein (EGFP) plasmid DNA Human liver carcinoma cells (HepG2), [71 ] Chitosan MDR1 siRNA BT325 cells [72 ] Chitosan Enhanced green fluorescent protein (EGFP) plasmid DNA Human embryonic kidney 293 (HEK293) cells Human A549 lung adenocarcinoma Human lung diploid cell line WI-38 (normal human fibroblast) cells Mouse heart and kidney [73 ] Dextran Carboxymethyl Green fluorescent protein (GFP) plasmid Human bladder cancer BIU-87 cells [74 ] Dextran Mouse anti-human β -HCG monoclonal antibody GAPDH AS-ODN JEG-3 JAR RL95-2 Hela HepG2 Lovo cells Nude mice [75 ] Dextran NK4 plasmid DNA [76 ] Hyaluronic acid Polyethylenimine (PEI) VR1020-PyMSP119 VR1020-YFP plasmids COS-7 cells C57BL/6 mice [77 ] Heparin Wild-type AAV2 AAVr3.45 Green fluorescent protein (GFP) HEK293T PC12 [78 ]