Polysaccharide-Coated Magnetic Nanoparticles for Imaging and Gene Therapy

Table 3

Strategies for polysaccharide coating MNPs for gene delivery.

Polysaccharide	Modification	Gene	In vitro/in vivo	Reference
Chitosan	Polyethylenimine (PEI); Poly(ethylene glycol) (PEG)	Enhanced green fluorescent protein (EGFP) plasmid DNA	C6 cells Xenograft C6 tumors	[69]
Chitosan	Hexanoyl chloride-modified	Viral gene (Ad/LacZ)	K562 cells; intestine and lung of balb-c mice	[70]
Chitosan	Poly(ethylene glycol) (PEG)	Enhanced green fluorescent protein (EGFP) plasmid DNA	Human liver carcinoma cells (HepG2),	[71]
Chitosan		MDR1 siRNA	BT325 cells	[72]
Chitosan		Enhanced green fluorescent protein (EGFP) plasmid DNA	Human embryonic kidney 293 (HEK293) cells; Human A549 lung; adenocarcinoma; Human lung diploid cell line; WI-38 (normal human fibroblast) cells; Mouse heart and kidney	[73]
Dextran	Carboxymethyl	Green fluorescent protein (GFP) plasmid	Human bladder cancer BIU-87 cells	[74]
Dextran	Mouse anti-human β-HCG monoclonal antibody	GAPDH AS-ODN	JEG-3; JAR; RL95-2; Hela; HepG2; Lovo cells; Nude mice	[75]
Dextran		NK4 plasmid DNA		[76]
Hyaluronic acid	Polyethylenimine (PEI)	VR1020-PyMSP119; VR1020-YFP plasmids	COS-7 cells; C57BL/6 mice	[77]
Heparin	Wild-type AAV2; AAVr3.45	Green fluorescent protein (GFP)	HEK293T; PC12	[78]