Variations in the Intragene Methylation Profiles Hallmark Induced Pluripotency

Figure 4

Enrichment analysis of the genes ranked by the misclassification error from the decision tree depth 1 classifier built on MEAN features and sorted in descending order. Horizontal scales indicate gene numbers. Left vertical scales indicate average errors (blue lines) and standard deviations (light blue areas). Black vertical dashed lines indicate the error level 10%. Right vertical scales and red curves indicate values for the enrichment of the best classifiers group, contained between gene #1 and a current gene, by (a) PCGT, (b) MESC, (c) H3K4, (d) H3K27, (e) bivalent, and (f) cancer gene groups. Green dashed lines indicate the null hypothesis rejection threshold of probability.

(a) PCGT

(b) MESC

(c) H3K4

(d) H3K27

(e) Bivalent

(f) Cancer