Variations in the Intragene Methylation Profiles Hallmark Induced Pluripotency

Figure 6

Enrichment analysis of the genes that are top-ranked by the random forest classifier built on the MEAN features and sorted according to their importance scores (blue lines and left vertical scales) in descending order. Red curves and right vertical scales indicate values for the enrichment of the best classifiers group, contained between gene #1 and a current gene, by (a) PCGT, (b) MESC, (c) H3K4, (d) H3K27, (e) bivalent, and (f) cancer gene groups. Horizontal scales indicate gene numbers. Green dashed line indicates the null hypothesis rejection threshold of 1% probability.

(a) PCGT

(b) MESC

(c) H3K4

(d) H3K27

(e) Bivalent

(f) Cancer