Variations in the Intragene Methylation Profiles Hallmark Induced Pluripotency

Table 1

ESCs versus iPSCs classification performance for linear regression and random forest based algorithms and for different types of intragene methylation measures, taken separately or together. Standard deviations of the estimates are given in parenthesis.

Features type	Type I error	Type II error	Misclassification; error
Logistic regression
MEAN	0.12 (0.15)	0.00 (0.00)	0.04 (0.05)
VAR	0.05 (0.10)	0.07 (0.08)	0.06 (0.05)
DEV	0.00 (0.00)	0.07 (0.08)	0.04 (0.05)
DERIV	0.00 (0.00)	0.03 (0.07)	0.02 (0.04)
ASYMM	0.00 (0.00)	0.03 (0.07)	0.02 (0.04)
All features	0.00 (0.00)	0.03 (0.07)	0.02 (0.04)
Random forest
MEAN	0.00 (0.00)	0.03 (0.07)	0.02 (0.04)
VAR	0.00 (0.00)	0.07 (0.08)	0.04 (0.05)
DEV	0.07 (0.13)	0.07 (0.08)	0.06 (0.05)
DERIV	0.00 (0.00)	0.07 (0.08)	0.04 (0.05)
ASYMM	0.07 (0.13)	0.07 (0.08)	0.06 (0.05)
All features	0.00 (0.00)	0.07 (0.08)	0.04 (0.05)