Effects of Chronic REM Sleep Restriction on D₁ Receptor and Related Signal Pathways in Rat Prefrontal Cortex

Figure 4

The scheme of signal pathways of D₁R. This simplified view of the signal pathways shows major downstream mediators between the two major pathways of D₁R. D₁R regulates CREB through PKA pathway (expressed by purple molecules) and MAPK pathway (yellow members), and the key molecules are marked by red. CREB was significantly decreased by CSR, while PKA showed a notable reduction (expressed by downward arrow).