MicroRNAs Based Therapy of Hypertrophic Cardiomyopathy: The Road Traveled So Far

Figure 1

Schematic representation of miRNA biogenesis and function. The biogenesis of miRNAs is initiated in the nucleus by the transcription of pri-miRNAs that, after hydrolyzation mediated by the RNAse Drosha, form pre-miRNA. After transport to the cytoplasm mediated by exportin 5, the loop of pre-miRNAs is cleaved by Dicer RNAse, forming the miRNA-duplex, which is incorporated in the RISC complex. The miRNA-duplex is then separated forming the mature miRNA that will inhibit translation by base pairing with the 3′UTR of the target mRNA.