MicroRNAs Based Therapy of Hypertrophic Cardiomyopathy: The Road Traveled So Far

Table 2

Resume of miRNAs based therapies targeting cardiomyocytes hypertrophy and fibrosis. The oligonucleotide modification, miRNA, the model used in the study, and the obtained result are depicted. LNA: locked nucleic acid.

	Oligonucleotide modification	miRNA	Model	Result	Ref.
AntimiR	AntagomiR	miR-133	C57BL/6 mice	Repression resulted in cardiac hypertrophic phenotype	[46]
	AntagomiR	miR-21	Heart failure induced by pressure overload mice	Repression reduces cardiac; ERK-MAP kinase activity, inhibits interstitial fibrosis, and attenuates; cardiac dysfunction	[66]
	AntagomiR	miR-132	Heart failure induced by pressure overload mice	Repression rescues heart hypertrophic phenotype	[67]
	LNA-modified oligonucleotide	miR-208a	Diastolic heart failure rats	Repression resulted in reduction of cardiac remodeling	[68]
RNA-mimic	Adenoviral vector; containing miR-133a-2 precursor sequence	miR-133	AKT induced heart hypertrophy mice	Overexpression resulted in attenuation of cardiac hypertrophic phenotype	[46]