Comparative Evaluation of Different Test Combinations for Diagnosis of Mycobacterium avium Subspecies paratuberculosis Infecting Dairy Herds in India

Table 3

Comparative diagnostic potential of different test combinations.

Test combinations	Kappa values	Strength of agreement	Relative sensitivity (95% CI)	Relative specificity (95% CI)
Serum ELISA–milk ELISA	0.325	Fair	0.470 (0.297–0.648)	0.870 (0.810–0.917)
Faecal Microscopy–faecal PCR	0.241	Fair	0.677 (0.554–0.788)	0.500 (0.381–0.608)
Milk ELISA–milk PCR	0.682	Substantial	0.793 (0.650–0.890)	0.938 (0.915–0.954)
Serum ELISA–faecal PCR	0.677	Substantial	0.833 (0.719–0.907)	0.844 (0.736–0.913)

<0.20, poor; 0.21–0.40, fair; 0.41–0.60, moderate; 0.61–0.80, substantial (good); and 0.81–100, almost perfect.