Clinical Study
Long-Term Clinical Outcome after Treatment for High-Grade Cervical Lesions: A Retrospective Monoinstitutional Cohort Study
Table 1
Principal characteristics of the 760 cases included in the study.
| | | % |
| Histological diagnosis at baseline | | | CIN2 | 415 | 54.6 | CIN3/in situ carcinoma | 330 | 43.4 | Microinvasive carcinoma | 15 | 2.0 |
| Colposcopic diagnosis at baseline | | | Negative | 87 | 11.4 | G1 (abnormal grade 1) | 378 | 49.7 | G2 (abnormal grade 2) | 279 | 36.7 | Suspected invasive carcinoma | 1 | 0.1 | Missing | 15 | 2.0 |
| Squamocolumnar junction location | | | Type 1 (visible, ectocervical) | 532 | 70.0 | Type 2 (visible, endocervical) | 158 | 20.8 | Type 3 (nonvisible, in endocervix) | 52 | 6.8 | Missing | 18 | 2.4 |
| Treatment | | | LEEP | 684 | 90.0 | Conization | 76 | 10.0 |
| Margins status of the excised specimens | | | Negative | 506 | 66.6 | Positive | 126 | 16.6 | Not assessable | 20 | 2.6 | Missing | 108 | 14.2 |
| HPV test at first follow-up | | | Negative | 350 | 48.5 | HPV 16 | 34 | 4.7 | Other high-risk HPV | 33 | 4.6 | Low-risk HPV | 89 | 12.2 | Not performed | 215 | 29.8 |
| Residual* lesions | | | CIN2 | 17 | 2.2 | CIN3 | 15 | 2.0 | Microinvasive carcinoma | 3 | 0.4 | Invasive carcinoma | 1 | 0.1 | VAIN2 | 2 | 0.3 | VAIN3 | 1 | 0.1 | Recurrent** lesions | | | CIN2 | 17 | 2.2 | CIN3 | 5 | 0.7 | VAIN2 | 5 | 0.7 | VAIN3 | 1 | 0.1 |
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Residual: lesions detected at first follow-up. **Recurrent: lesions detected after one or more negative follow-up visits.
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