Long-Term Clinical Outcome after Treatment for High-Grade Cervical Lesions: A Retrospective Monoinstitutional Cohort Study
Table 2
Multivariate logistic regression analyses to identify predictive factors of the risk of residual or recurrent high-grade lesions in 760 women treated for CIN2+ (upper part) and among 506 women without residual high-grade disease at first follow-up visit who had a HPV test (lower part). Only variables that resulted significant after a forward-stepwise selection are reported.
Women treated for CIN2+ ()
Variable
Risk of residual or recurrent CIN2
Risk of residual or recurrent CIN3+
Odds ratio∧ (95% CI)
value
Odds ratio∧ (95% CI)
value
Histological diagnosis at baseline
CIN2*
1.00
—
CIN3+
6.02 (1.73–20.9)
0.005
Margins status of the excised lesions
Negative*
1.00
—
1.00
—
Positive
5.11 (2.42–10.8)
<0.001
13.8 (4.98–38.5)
<0.001
Women without residual high-grade disease at first follow-up visit with HPV test ()
Variable
Risk of recurrent CIN2
Risk of recurrent CIN3
Odds ratio∧ (95% CI)
value
Odds ratio∧ (95% CI)
value
Histological diagnosis at baseline
CIN2*
1.00
—
CIN3+
0.4 (0.12–1.29)
0.125
Squamocolumnar junction location
Type 1*
1.00
—
Type 2
1.68 (0.14–20.5)
0.68
Type 3
27.7 (2.07–369)
0.012
Colposcopic diagnosis at baseline
G1*
1.00
—
G2
4.17 (1.28–13.6)
0.018
Negative
1.67 (0.37–7.61)
0.503
HPV test at first follow-up
Negative*
1.00
—
1.00
—
HPV 16
13.3 (3.48–50.5)
<0.001
63.6 (4.45–909)
0.002
Other high-risk HPV
22.3 (5.69–87.3)
<0.001
7.76 (0.42–142)
0.168
Low-risk HPV
2.94 (0.67–12.8)
0.152
—†
—
Reference. ∧Adjusted for all the variables in the table. Nonsignificant, excluded from the model. †No CIN3+ events in the Low-risk group, excluded from the model.