Associations of Polymorphisms in HRH2, HRH3, DAO, and HNMT Genes with Risk of Chronic Heart Failure
Table 3
Genotype and allele distribution of HRH2, HRH3, DAO, and HNMT polymorphisms and their associations with the risk of CHF.
Genotype
CHF
Control
Unadjusted
Adjusted
Adjusted
HWE
(%)
(%)
OR (95% CI)
HRH2
rs2067474
GG
240 (72.1)
251 (70.9)
0.477
0.725
0.943 (0.682–1.306)
0.175
GA
86 (25.8)
90 (25.4)
AA
7 (2.1)
13 (3.7)
G/A allele
566/100
592/116
0.505
0.720
0.941 (0.676–1.311)
rs1800689
GG
311 (93.4)
325 (91.8)
0.341
0.709
0.886 (0.470–1.671)
0.422
GA
21 (6.3)
29 (8.2)
AA
1 (0.3)
0 (0.0)
G/A allele
643/23
679/29
0.573
0.709
0.886 (0.468–1.675)
HRH3
rs3787429
CC
197 (59.2)
143 (40.4)
<0.001
0.001
0.662 (0.523–0.838)
0.067
CT
88 (26.4)
151 (42.7)
TT
48 (14.4)
60 (16.9)
C/T allele
482/184
437/271
<0.001
<0.001
0.608 (0.470–0.786)
rs3787430
CC
229 (68.8)
226 (63.8)
0.371
0.274
0.848 (0.632–1.139)
0.483
CT
89 (26.7)
111 (31.4)
TT
15 (4.5)
17 (4.8)
C/T allele
547/119
563/145
0.244
0.258
0.839 (0.619–1.137)
DAO
rs2268999
AA
249 (74.8)
263 (74.3)
0.789
0.972
0.994 (0.700–1.411)
0.634
AT
79 (23.7)
83 (23.4)
TT
5 (1.5)
8 (2.3)
A/T allele
577/89
609/99
0.754
0.972
0.994 (0.701–1.409)
rs10156191
CC
243 (73.0)
269 (76.0)
0.071
0.065
1.391 (0.980–1.975)
0.228
CT
79 (23.7)
82 (23.2)
TT
11 (3.3)
3 (0.8)
C/T allele
565/101
620/88
0.158
0.064
1.388 (0.981–1.964)
rs1049742
CC
333 (100)
353 (99.7)
1.000
1.000
—
0.979
CT
0 (0.0)
1 (0.3)
TT
0 (0.0)
0 (0.0)
C/T allele
666/0
707/1
1.000
1.000
—
rs2071514
GG
99 (29.7)
95 (26.8)
0.460
0.511
0.922 (0.724–1.174)
0.932
GA
168 (50.5)
176 (49.7)
AA
66 (19.8)
83 (23.4)
G/A allele
366/300
366/342
0.234
0.514
0.923 (0.726–1.174)
rs1049748
CC
111 (33.3)
141 (39.8)
0.177
0.420
1.108 (0.864–1.421)
0.686
CT
174 (52.3)
162 (45.8)
TT
48 (14.4)
51 (14.4)
C/T allele
396/270
444/264
0.223
0.138
1.204 (0.942–1.540)
rs1049793
CC
83 (24.9)
78 (22.0)
0.589
0.513
0.923 (0.727–1.172)
0.739
CG
162 (48.6)
173 (48.9)
GG
88 (26.4)
103 (29.1)
C/G allele
328/338
329/379
0.305
0.511
0.923 (0.726–1.173)
HNMT
rs11558538
CC
307 (92.2)
320 (90.4)
0.421
0.866
0.951 (0.530–1.707)
0.343
CT
26 (7.8)
34 (9.6)
TT
0 (0.0)
0 (0.0)
C/T allele
640/26
674/34
0.431
0.870
0.953 (0.539–1.686)
HWE: Hardy-Weinberg equilibrium. Bonferroni’s multiple adjustment was applied to the level of significance, which was set at (0.05/11 SNPs). values were calculated from two-sided chi-square tests or Fisher’s exact tests. and OR (95% CI) values were calculated by logistic regression adjusted for age, gender, body mass index, and traditional cardiovascular risk factors. HWE P values for control group were calculated from two-sided chi-square tests or Fisher’s exact tests.
