Associations of Polymorphisms in HRH2, HRH3, DAO, and HNMT Genes with Risk of Chronic Heart Failure

Table 5

Genotype distribution of HRH3 rs3787429 polymorphism according to NYHA class and subsets of CHF patients.

	rs3787429			Genotype distribution	Allele frequency
	CC ()	CT ()	TT ()	P value	P value
NYHA (%)
II	53 (54.1)	32 (32.7)	13 (13.3)	0.282	0.247
III	74 (56.9)	35 (26.9)	21 (16.2)
IV	70 (66.7)	21 (20.0)	14 (13.3)
Hypertension (%)	120 (59.4)	54 (26.7)	28 (13.9)	<0.001	<0.001
Dyslipidemia (%)	66 (55.5)	38 (31.9)	15 (12.6)	0.017	0.008
Diabetes (%)	64 (60.4)	25 (23.6)	17 (16.0)	0.001	0.005
Smokers (%)	70 (56.0)	36 (28.8)	19 (15.2)	0.008	0.014
Ischemic (%)	110 (61.1)	46 (25.6)	24 (13.3)	<0.001	<0.001
Non ischemic (%)	87 (56.9)	42 (27.5)	24 (15.7)	0.001	0.008
LVEF (%)	33.6 ± 6.8	33.4 ± 6.8	31.9 ± 7.9	0.319	—

LVEF: left ventricular ejection fraction; NYHA: New York Heart Association.
P values were calculated from two-sided Fisher’s exact tests to analyze the genotype distribution or allele frequency for the HRH3 rs3787429 polymorphism according to NYHA class.
P values were calculated from two-sided chi-square tests or Fisher’s exact tests versus the control population.
P values were calculated by analysis of variance (ANOVA).