Rapid Identification of Potential Drugs for Diabetic Nephropathy Using Whole-Genome Expression Profiles of Glomeruli

Table 3

Top 20 drug perturbations with high negative connectivity scores.

Rank	Instance ID	CMAP name	Dose	Cell	Score	Up	Down
1	1274	Bepridil	10 µM	HL60	−1	−0.077	0.223
2	7063	MG-262	100 nM	MCF7	−0.96	−0.163	0.125
3	7345	Alcuronium chloride	5 µM	MCF7	−0.953	−0.108	0.178
4	942	Prazosin	10 µM	MCF7	−0.953	−0.111	0.175
5	1764	Piperlongumine	13 µM	HL60	−0.94	−0.071	0.212
6	7022	Dyclonine	12 µM	MCF7	−0.931	−0.104	0.175
7	3351	(±)-Catechin	14 µM	MCF7	−0.923	−0.126	0.151
8	7017	Mesoridazine	7 µM	MCF7	−0.922	−0.101	0.176
9	909	HC toxin	100 nM	MCF7	−0.921	−0.107	0.17
10	1694	Metformin	24 µM	MCF7	−0.909	−0.102	0.17
11	1656	15d-PGJ2	10 µM	MCF7	−0.901	−0.112	0.158
12	7020	Xylometazoline	14 µM	MCF7	−0.898	−0.1	0.17
13	1058	Vorinostat	10 µM	MCF7	−0.898	−0.12	0.15
14	7178	Tetrandrine	6 µM	MCF7	−0.897	−0.151	0.118
15	1069	15d-PGJ2	10 µM	MCF7	−0.895	−0.12	0.149
16	1140	MG-132	21 µM	MCF7	−0.884	−0.122	0.143
17	1112	Trichostatin A	100 nM	MCF7	−0.882	−0.104	0.161
18	6936	Chlorpromazine	1 µM	MCF7	−0.88	−0.115	0.149
19	5310	Puromycin	7 µM	MCF7	−0.874	−0.111	0.151
20	5304	Moroxydine	19 µM	MCF7	−0.874	−0.125	0.137

Instance: a treatment and control pair and the list of probe sets ordered by their extent of differential expression between this treatment and control pair; instance ID: the ID uniquely identifying each instance; CMAP name: the name given to a perturbagen; dose: perturbagen dose; cell: cell line; up: the up score, a value between +1 and −1 representing the absolute enrichment of an up tag list in a given instance; down: the down score, a value between +1 and −1 representing the absolute enrichment of a down tag list in a given instance; score: the connectivity score, a combination of the up score and the down score. A high negative connectivity score indicates that the corresponding perturbagen reversed the expression of the query signature.