Rapid Identification of Potential Drugs for Diabetic Nephropathy Using Whole-Genome Expression Profiles of Glomeruli

Table 4

Top 20 drug perturbations with high reversing scores.

Perturbagen name-instance ID	Score	Reversed	Aggravated
Vorinostat-6179	46	75	29
15d-PGJ2-1231	43	65	22
Piperlongumine-1764	36	55	19
Resveratrol-662	34	54	20
Ciclopirox-2456	33	67	34
Resveratrol-1715	32	59	27
LY-294002-6186	32	63	31
Valproic acid-410	31	53	22
Trichostatin A-1175	31	59	28
Ethoxyquin-3764	31	57	26
0173570-0000-7389	31	68	37
Parthenolide-1736	30	47	17
Ellipticine-1765	30	46	16
Etoposide-3241	30	73	43
Withaferin A-3819	30	68	38
Vorinostat-1161	29	57	28
Naproxen-2533	29	63	34
Rosiglitazone-2693	29	55	26
Monobenzone-3391	29	74	45
Alclometasone-5752	29	63	34

Perturbagen name: the name given to a perturbagen; instance ID: the ID uniquely identifying each instance; score: the reversing score calculated using formula (1); reversed: number of genes in the query signature, the expression of these genes was reversed by the corresponding perturbagen; aggravated: number of genes in the query signature, the expression of these genes was aggravated by the corresponding perturbagen.