Review Article
Effects of Exercise Interventions and Physical Activity Behavior on Cancer Related Cognitive Impairments: A Systematic Review
Table 2
Exercise interventions in rodents.
| Reference | | Study design | Study population | Treatment | Type of exercise | Duration | Parameters |
| Chemotherapy | Winocur et al., 2014 [33] | 38 9 MTX/5FU Run 10 MTX/5FU 9 CG Run 9 CG | 2 × 2 RCT | f, Long-Evans rats | 37.8 mg/kg MTX + 50 mg/kg 5FU or salt solution | Access to a running wheel | 11 weeks | SM () CM () NMTS () DNMTS () Hippocampal neurogenesis () | Fardell et al., 2012 [34] | 28 7 5FU/OX Run 7 5FU/OX 7 CG Run 7 CG | 2 × 2 RCT | m, hooded Wistar rats | 75 mg/kg FU + 8 mg/kg OX or salt solution | Access to a running wheel overnight | 6 weeks | NOR () MWM () |
| Cranial radiation | Ji et al., 2014 [32] | 104 16 20 Gy Run 16 20 Gy 16 CG Run 16 CG | 2 × 2 RCT | Sprague-Dawley rats | 20 Gy or sham radiation | 30 min access to a running wheel in the morning and evening | 5x/week over 3 weeks | Open-field test () MWM () BDNF () Hippocampal neurogenesis () | Wong-Goodrich et al., 2010 [35] | 40 10 5 Gy Run 10 5 Gy 10 CG Run 10 CG | 2 × 2 RCT | f, C57BL/6 mice | 5 Gy or sham radiation | Access to a running wheel 8/12 hours per day | 16 weeks | Barnes Maze () Hippocampal neurogenesis () Growth factor expression () | Naylor et al., 2008 [36] | 16 4 6 Gy Run 4 6 Gy 4 CG Run 4 CG | 2 × 2 RCT | C57BL/6 mice | 6 Gy or sham radiation | Access to a running wheel | 4 weeks | Open-field test () Hippocampal neurogenesis () |
|
|
5FU: 5-Fluorouracil; OX: Oxaliplatin; CG: control group; Gy: Gray; RCT: Randomized Controlled Trial; m: male; f: female; NOR: Novel Object Recognition; MWM: Morris Water Maze; SM: spatial memory; CM: Cued Memory; NMTS: Non-Matching to Sample Task, DNMTS: Delayed Non-Matching to Sample task.
|