Effects of Exercise Interventions and Physical Activity Behavior on Cancer Related Cognitive Impairments: A Systematic Review

Table 2

Exercise interventions in rodents.

Reference		Study design	Study population	Treatment	Type of exercise	Duration	Parameters
Chemotherapy
Winocur et al., 2014 [33]	38; 9 MTX/5FU Run; 10 MTX/5FU; 9 CG Run; 9 CG	2 × 2; RCT	f, Long-Evans rats	37.8 mg/kg MTX + 50 mg/kg 5FU or salt solution	Access to a running wheel	11 weeks	SM (); CM (); NMTS (); DNMTS (); Hippocampal neurogenesis ()
Fardell et al., 2012 [34]	28; 7 5FU/OX Run; 7 5FU/OX; 7 CG Run; 7 CG	2 × 2; RCT	m, hooded Wistar rats	75 mg/kg FU + 8 mg/kg OX or salt solution	Access to a running wheel overnight	6 weeks	NOR (); MWM ()
Cranial radiation
Ji et al., 2014 [32]	104; 16 20 Gy Run; 16 20 Gy; 16 CG Run; 16 CG	2 × 2; RCT	Sprague-Dawley rats	20 Gy or sham radiation	30 min access to a running wheel in the morning and evening	5x/week over 3 weeks	Open-field test (); MWM (); BDNF (); Hippocampal neurogenesis ()
Wong-Goodrich et al., 2010 [35]	40; 10 5 Gy Run; 10 5 Gy; 10 CG Run; 10 CG	2 × 2; RCT	f, C57BL/6 mice	5 Gy or sham radiation	Access to a running wheel 8/12 hours per day	16 weeks	Barnes Maze (); Hippocampal neurogenesis (); Growth factor expression ()
Naylor et al., 2008 [36]	16; 4 6 Gy Run; 4 6 Gy; 4 CG Run; 4 CG	2 × 2; RCT	C57BL/6 mice	6 Gy or sham radiation	Access to a running wheel	4 weeks	Open-field test (); Hippocampal neurogenesis ()

5FU: 5-Fluorouracil; OX: Oxaliplatin; CG: control group; Gy: Gray; RCT: Randomized Controlled Trial; m: male; f: female; NOR: Novel Object Recognition; MWM: Morris Water Maze; SM: spatial memory; CM: Cued Memory; NMTS: Non-Matching to Sample Task, DNMTS: Delayed Non-Matching to Sample task.