Proteomic Profiling of Neuroblastoma Cells Adhesion on Hyaluronic Acid-Based Surface for Neural Tissue Engineering

Table 3

Proteins identified by the higher confidence level (at least three unique peptide sequences matched) in the PC12 CM which were involved in neuron generation function.

Accession numbers	Protein name	Biological process	Molecular function
Q66HC8	Gametogenetin	Cell differentiation
		Double-strand break repair
		Embryo implantation
		Spermatogenesis
P43145	ADM	Aging	Adrenomedullin receptor binding
		Androgen metabolic process
		Calcium ion homeostasis
		cAMP-mediated signaling
		Hormone secretion
		Vasculogenesis
		Cell proliferation
		Apoptotic process
Q9JKU6	Spermatid perinuclear RNA-binding protein	Cell differentiation	DNA binding
		Multicellular organismal development	RNA binding
		Spermatogenesis
O35569	Pro-neuregulin-2, membrane-bound isoform	Epidermal growth factor receptor signaling pathway	Epidermal growth factor receptor binding
		Intracellular signal transduction	ErbB-3 class receptor binding
		Organ development
Q62956	Receptor tyrosine-protein kinase erbB-4	Cardiac muscle tissue regeneration	ATP binding
		Cell migration	Receptor signaling protein tyrosine kinase activity
		Nervous system development	Transmembrane receptor protein tyrosine kinase activity
		Apoptotic process
		Cell proliferation
		Glucose import
		Odontogenesis
		Protein tyrosine kinase Signaling pathway
P01026	Complement C3	Blood coagulation	C5L2 anaphylatoxin chemotactic receptor binding
		Chemotaxis	Cofactor binding
		Fatty acid metabolic process	Endopeptidase inhibitor activity
		Inflammatory response	Lipid binding
		Glucose transport
		Triglyceride biosynthetic process
		Response to progesterone and estrogen
Q9R172	Neurogenic locus notch homolog protein 3	Cell differentiation	Calcium ion binding
		Multicellular organismal development
		Notch signaling pathway
		Regulation of transcription, DNA-templated
		Tissue regeneration