Substance P Receptor Signaling Mediates Doxorubicin-Induced Cardiomyocyte Apoptosis and Triple-Negative Breast Cancer Chemoresistance

Figure 1

Effect of substance P receptor antagonist pretreatment on doxorubicin-induced cardiomyocyte growth inhibition and triple-negative breast cancer cell chemoresistance. Levels of viability as determined by the MTT assay, in response to DOX in aprepitant pretreated versus untreated rat H9C2 cardiomyocytes (a and b) and MDA-MB 231 TNBC cells (c and d) (, ANOVA, , for both).

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