Curcumin Downregulates Phosphate Carrier and Protects against Doxorubicin Induced Cardiomyocyte Apoptosis

Figure 1

Oxidative stress showed obvious increase with time after addition of doxorubicin and this was alleviated by curcumin. ( versus Negative control (Dox 0 h-Cur 0 min)) ( versus Cur 0, Dox + at each time point). (a) Following culture with doxorubicin, GSH levels declined with time while curcumin obviated this effect at various doses. (b) SOD activity decreased with time after culture with doxorubicin, and this effect was decreased by curcumin at various doses. (c) Doxorubicin culture increased MDA content over time, an effect that was attenuated by curcumin. 12 mg/L was the most efficient dose of curcumin in decreasing MDA content following culture with doxorubicin.

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