Utilizing Autologous Multipotent Mesenchymal Stromal Cells and -Tricalcium Phosphate Scaffold in Human Bone Defects: A Prospective, Controlled Feasibility Trial

Figure 6

(a) Anteroposterior radiograph of a 68-year-old man (case number 6; trial group) with aseptic loosening of the femoral component which migrated into the varus position with contemporary formation of the medial bone defect of the femur; the femoral component is inside the bone defect. (b) Complete filling of the bone defect with tricalcium phosphate synthetic graft material combined with expanded multipotent mesenchymal stromal cells (MSCs) immediately after surgery. (c) Disappearing rim radiolucency surrounding the grafted defect distomedially at 6 weeks after surgery. (d) Initial peripheral resorption of the graft material combined with expanded MSCs at 12 weeks after surgery. (e) Gradual resorption within the grafted defect at 6 months after surgery. (f) Peripheral bone trabeculation through the defect at 9 months after surgery. (g) Complete resorption of tricalcium phosphate synthetic graft material with trabecular remodeling at 12 months after surgery. All described bone changes are marked by an arrow.

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