Potential Roles of Amiloride-Sensitive Sodium Channels in Cancer Development

Figure 1

Contribution of ENaC/ASIC mediating Na⁺ current to cell volume in cancer cell development. ENaC/ASIC mediating Na⁺ influx promoted the proliferation, migration, and invasion of cancer cell, compared to blockage of this Na⁺ influx inducing cell cycle arrest and apoptosis of cancer cell.