Human Umbilical Cord Mesenchymal Stem Cells Therapy in Cyclophosphamide-Induced Premature Ovarian Failure Rat Model

Figure 9

The network of steroidal hormones regulation system during pathological process of POF and UCMSCs therapeutic mechanism. With the hypothalamus regulation, adenohypophysis could synthesize and produce gonadotropins (FSH), which could stimulate follicles growth. GCs of the growth follicles could produce E2, having a feedback negative effect on FSH production, thus reducing follicles excessive growth and avoiding their depletion. AMH could also inhibit FSH production. The negative feedback effect of E2 and AMH on the follicles growth was interrupted by CTX administration. Lack of inhibition of E2 and AMH causes uncontrolled elevating FSH level, which promotes follicles pool exhausted very soon, leading to POF. The transplanted human UCMSCs may secrete kinds of growth factors, which could rescue the overapoptosis of GCs and ultimately improve follicles development and retargeted hormonal balance.