Effect of Ulinastatin in the Treatment of Postperative Cognitive Dysfunction: Review of Current Literature

Table 2

Secondary outcomes reported by included studies.

Study

IL-6 (pg/mL)

TNF-α (pg/mL)

CRP (mg/L)

S100β (ug/L)

U

C

U

C

U

C

U

C

Xu et al., 2013 [26]

Kang et al., 2010 [25]

—

—

—

—

—

—

Shan et al., 2015 [27]

—

—

—

—

—

—

Ge et al., 2015 (1) [28]

—

—

Ge et al., 2015 (2) [28]

—

—

Note: U: ulinastatin group; C: control group; preoperative; at the end of operation; three hours after operation; six hours after operation; one day after operation; two days after operation; three days after operation; from preoperation in group U and group C (statistically significant); from group C (statistically significant). Ge et al., 2015 (1): high-dose ulinastatin (16000 U/kg); Ge et al., 2015 (2): low-dose ulinastatin (8000 U/kg).