Menoprogen, a TCM Herbal Formula for Menopause, Increases Endogenous E₂ in an Aged Rat Model of Menopause by Reducing Ovarian Granulosa Cell Apoptosis

Figure 2

Effects of Menoprogen on GC apoptosis using the TdT-mediated dUTP nick end-labeling (TUNEL) assay. Apoptotic cells were detected as TUNEL-positive cells (brown staining). (a) Light microscopy showed many developing follicles at different stages and corpora lutea in normal control group. (b) In the NAM group there were more atretic follicles and apoptotic expression was prominent. (c, d) There were more developing follicles at different stages in the Menoprogen-treated (c) group and the Progynova group (d) (200x).

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