An Efficient Approach to Screening Epigenome-Wide Data

Figure 6

Top pathways enriched among genes identified by training and testing method from the Isle of Wight data include aryl hydrocarbon receptor signaling and xenobiotic metabolism signaling, which overlap with other pathways including the nicotine degradation II and nicotine degradation III pathways, as well as pathways for the metabolism of cigarette smoke components and producing known effects of smoke exposure.