Research Article
An Efficient Approach to Screening Epigenome-Wide Data
Table 2
Simulation results for selecting
important variables among 2,000 candidates with surrogate variables excluded.
| Statistics | Bon | FDR | TT | Bon | FDR | TT |
| Random error normally distributed |
| | | | # incorrect | 10 | 51 | 9 | 99 | 114 | 90 | Sensitivity | 0.011 | 0.054 | 0.100 | 0.014 | 0.167 | 0.102 | Specificity | 1 | 0.979 | 1 | 1 | 0.984 | 1 |
| | | | # incorrect | 197 | 182 | 180 | 394 | 310 | 359 | Sensitivity | 0.015 | 0.232 | 0.102 | 0.015 | 0.288 | 0.104 | Specificity | 1 | 0.984 | 1 | 1 | 0.984 | 1 |
| Random error distributed (df = 1) |
| | | | # incorrect | 10 | 38 | 9 | 98 | 103 | 91 | Sensitivity | 0.018 | 0.053 | 0.095 | 0.015 | 0.158 | 0.096 | Specificity | 1 | 0.986 | 1 | 1 | 0.99 | 1 |
| | | | # incorrect | 197 | 176 | 181 | 394 | 314 | 363 | Sensitivity | 0.014 | 0.217 | 0.094 | 0.014 | 0.273 | 0.095 | Specificity | 1 | 0.989 | 1 | 1 | 0.986 | 1 |
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Bon: Bonferroni, FDR: false discovery rate, and TT: training and testing.
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