Herpes Simplex Virus Type 1 and Type 2 Infection Increases Atherosclerosis Risk: Evidence Based on a Meta-Analysis

Table 1

Characteristics of literatures included in the meta-analysis concerning HSV-1.

First author	Year	Country	Region	Disease type	Test method	Male proportion	Age	Sample size	Case size		Control size
									HSV-1 (+)	HSV-1 (−)	HSV-1 (+)	HSV-1 (−)
Jafarzadeh [24]	2011	Iran	Asian	Myocardial ischemia	ELISA	59%	54	180	73	47	20	40
Heltai [25]	2004	Hungary	European	Myocardial ischemia	ELISA	—	—	129	59	24	32	14
Vahdat [26]	2007	Iran	Asian	Myocardial ischemia	ELISA	49%	—	1754	198	24	1327	205
Mundkur [17]	2012	UK	European	Myocardial ischemia	ELISA	68%	53	866	240	193	214	219
Prasad [27]	2002	America	American	Myocardial ischemia	ELISA	61%	56	375	211	35	102	27
Georges [28]	2003	Germany	European	Myocardial ischemia	ELISA	73%	62	1324	922	69	280	53
Lindberg [29]	1997	Sweden	European	Carotid artery disease	SPRIA	—	—	534	198	69	190	77
Siscovick [13]	2000	America	American	Myocardial ischemia	WB	63%	74	618	191	22	333	72
Guan [15]	2012	China	Asian	Myocardial ischemia	ELISA	62%	56	252	71	31	60	90
Zhu [30]	2000	America	American	Myocardial ischemia	ELISA	63%	57	233	133	25	59	16
Kis [14]	2007	Hungary	European	Stroke	ELISA	58%	52	111	24	35	8	44
Adam [31]	1987	America	American	Mixed AS lesions	SPRIA	100%	58	226	75	38	69	44
Sorlie [16]	2000	America	American	Myocardial ischemia	SPRIA	52%	55	726	166	55	379	126
Al-Ghamdi [6]	2012	Saudi Arabia	Asian	Mixed AS lesions	ELISA	64%	56	90	72	3	14	1
Pan [32]	2005	China	Asian	Myocardial ischemia	ELISA	48%	62	127	46	16	22	43
Pan [33]	1999	China	Asian	Myocardial ischemia	ELISA	70%	—	60	24	6	22	8
Liu [34]	2004	China	Asian	Myocardial ischemia	ELISA	73%	67	124	72	21	19	12

HSV-1: herpes simplex virus type 1; ELISA: enzyme-linked immunosorbent assay; SPRIA: solid-phase radioimmunoassay; WB: western blot; AS: atherosclerosis.