Herpes Simplex Virus Type 1 and Type 2 Infection Increases Atherosclerosis Risk: Evidence Based on a Meta-Analysis
Table 3
Pooled OR and 95% CI of stratified meta-analysis.
Variables
HSV-1
HSV-2
OR (95% CI)
value
(%)
OR (95% CI)
value
(%)
Total
17
1.77 (1.40–2.23)
<0.001
65.6
<0.001
7
1.37 (1.13–1.67)
0.002
38.2
0.138
Disease type
Myocardial ischemia
13
1.83 (1.40–2.40)
<0.001
69.6
<0.001
4
1.66 (1.28–2.15)
<0.001
<0.001
0.409
Other types of AS
4
1.37 (1.02–1.83)
0.035
45.8
0.137
3
1.05 (0.77–1.41)
0.777
<0.001
0.410
Region
Asian
7
2.49 (1.57–3.97)
<0.001
61.3
0.017
2
1.47 (0.75–2.86)
0.261
59.4
0.116
European
5
1.63 (1.09–2.42)
0.017
73.2
0.005
3
1.40 (0.87–2.26)
0.168
61.9
0.072
American
5
1.32 (1.06–1.65)
0.014
11.9
0.338
2
1.22 (0.82–1.83)
0.323
22.2
0.257
Male proportion
≤60%
5
2.26 (1.19–4.30)
0.013
84.0
<0.001
2
1.26 (0.75–2.13)
0.381
3.6
0.308
>60%
10
1.80 (1.40–2.31)
<0.001
47.9
0.044
4
1.61 (1.25–2.07)
<0.001
26.8
0.251
Age
≤60-year-old
9
1.74 (1.26–2.41)
0.001
67.4
0.002
5
1.41 (1.08–1.85)
0.012
14.9
0.320
>60-year-old
4
2.52 (1.92–3.30)
<0.001
46.5
0.132
1
1.85 (1.20–2.85)
0.005
—
—
HSV-1: herpes simplex virus type 1; HSV-2: herpes simplex virus type 2; AS: atherosclerosis; OR: odds ratio; : the value of heterogeneity; —: no data. The results were in bold, if the 95% CI excluded 1 or .
