Carnitine and/or Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia
Table 1
Mean ± SD ammonia, CAR, and ALCAR levels and ACYLCAR/CAR ratio in patients with PHT (Group A) and in patients with VPA (Group B). Mean plasma VPA concentrations of patients in Group B are also shown.
Ammonia ± SD (μg/dL)
VPA ± SD (mg/L)
CAR ± SD (μmol/L)
ALCAR ± SD (μmol/L)
ACYLCAR/CAR ± SD
Group A
61.7 ± 27.3
37.8 ± 8.6
11.5 ± 3.0
0.35 ± 0.15
Group B
105.2 ± 57.2
39.8 ± 13.0
12.6 ± 5.5
0.45 ± 0.13
value
0.005
NS
NS
0.0005
Normal values in healthy individuals
25–94
19–59
>9.8
0.1–0.40
Group B
With hyperammonemia
140.0 ± 47.7
44.9 ± 29.8
34.9 ± 11.4
9.9 ± 3.0
0.44 ± 0.13
Without hyperammonemia
54.6 ± 19.7
30.1 ± 20.3
44.5 ± 10.3
17.4 ± 5.7
0.47 ± 0.11
Significantly different from the corresponding value in Group A.
