Prediction and Prevention of Acute Kidney Injury after Cardiac Surgery

Table 1

RIFLE, AKIN, and KDIGO classification for AKI diagnosis.

RIFLE		AKIN		KDIGO		Urine output
Criteria	Creatinine definition	Criteria	Creatinine definition	Criteria	Creatinine definition
Risk	≥1.5-fold increase from baseline SCr; or decrease in GFR ≥25%	Stage 1	≥0.3 mg/dL increase or ≥1.5-fold increase from baseline SCr within 48 hrs	Stage 1	≥0.3 mg/dL increase within 48 hrs or 1.5–1.9 times baseline within 7 days	<0.5 mL/kg/h for >6 hours
Injury	≥2-fold increase from baseline SCr; or decrease in GFR ≥50%	Stage 2	≥2-fold increase from baseline SCr	Stage 2	2.0–2.9 times baseline within 7 days	<0.5 mL/kg/h for 12 hours
Failure	≥3-fold increase from baseline SCr; or increase to ≥4 mg/dL or decrease in GFR ≥75%	Stage 3	≥3-fold increase from baseline SCr or increase to ≥4.0 mg/dL with an acute increase of >0.5 mg/dL; or initiation of RRT	Stage 3	≥3 times baseline within 7 days or increase to ≥4.0 mg/dL with an acute increase of >0.5 mg/dL; or initiation of RRT	<0.3 mL/kg/h for 24 hours or anuria for >12 hours

RIFLE: risk, injury, failure, loss, end-stage kidney disease; AKIN: acute kidney injury network; KDIGO: kidney disease: improving global outcomes; SCr: serum creatinine; GFR: glomerular filtration rate; RRT: renal replacement therapy.
Urine output criteria are common to three definitions.