Phosphoprotein Phosphatase 1 Is Required for Extracellular Calcium-Induced Keratinocyte Differentiation

Figure 10

The proposed model. A proposed model for the signaling pathway of calcium-induced keratinocyte differentiation. In high calcium conditions, PP1 is recruited to the calcium-dependent E-cadherin-β-catenin-PIP5K1α complex in the plasma membrane to activate PIP5K1α, which increases the synthesis of the substrate PIP₂ for both PLC-γ1 and PI3K. PLC-γ1 hydrolyzes PIP₂ to IP₃, which in turn increases calcium concentration leading to keratinocyte differentiation.