Transcriptional Regulation of lncRNA Genes by Histone Modification in Alzheimer’s Disease

Figure 1

Positive association between expression level of differential lncRNA genes and H3K4me3 modification level in promoters of the differential lncRNA genes. (a) Scatter diagram and a fitting line show the positive association between fold change of lncRNA gene expression and fold change of H3K4me3 modification level in the promoter. (b) Boxplot of expression level of differential lncRNA genes and H3K4me3 modification level in the promoters of the differential lncRNA genes in AD and control samples, respectively, which shows that lncRNA genes with high H3K4me3 level in the promoters have high expression level. The circle in (b) refers to a singular point in statistics, differential from other points. But the singular point has statistical significance, showing the accuracy and objectivity of this article.

(a)

(b)