Transcriptional Regulation of lncRNA Genes by Histone Modification in Alzheimer’s Disease

Figure 2

Negative association between expression level of differential lncRNA genes and H3K27me3 modification level in promoters of the differential lncRNA genes. (a) Scatter diagram and a fitting line show the negative association between fold change of expression level of differential lncRNA genes and fold change of H3K27me3 modification level in the promoters. (b) Boxplot of expression level of differential lncRNA genes and H3K27me3 modification level in the promoters of the differential lncRNA genes in AD and control samples, respectively, which shows that lncRNA genes with high H3K27me3 level in the promoters have low expression level. The circle in (b) refers to a singular point in statistics, differential from other points. But the singular point has statistical significance, showing the accuracy and objectivity of this article.

(a)

(b)