Research Article
Comparison of Neuroprotective Effect of Bevacizumab and Sildenafil following Induction of Stroke in a Mouse Model
Table 2
Penumbra, stroke, and brain edema in sildenafil-, bevacizumab- (immediate and 6 h), and saline-treated MCAO induced mice.
| Treatment | | Mean penumbra area (mm3) | Mean stroke area (mm3) | Total stroke area (mm3) | Total injured hemisphere (mm3) | % of injured hemisphere | Normal hemisphere | Hemispheric asymmetry (ratio) |
| Sildenafil | 16 | 5.7 ± 2.02 | 12.72 ± 6.76 | 18.42 ± 5.41 | 32.63 ± 1.60 | 56.10 ± 15.31 | 29.68 ± 3.13 | 1.099 |
| Bevacizumab | 19 | 7.3 ± 3.5 | 10.50 ± 5.53 | 17.79 ± 5.80 | 34.67 ± 2.04 | 51.0 ± 15.52 | 31.89 ± 3.25 | 1.086 | 7 | 2.4 ± 2.0 | 7.40 ± 5.42 | 9.80 ± 8.00 | 32.90 ± 2.93 | 29.00 ± 22.3 | 33.51 ± 2.23 | 0.982 |
| Saline | 16 | 4.5 ± 2.03 | 14.70 ± 6.75 | 19.20 ± 6.38 | 32.72 ± 2.95 | 58.09 ± 16.7 | 30.70 ± 3.20 | 1.065 |
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versus saline and versus sildenafil.
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