Species Rack1 Functions References Ascomycetes Saccharomyces cerevisiae Asc1 General amino acid control, pheromone response, mating and filamentous growth, pseudohyphal development, translation regulation and fidelity, cell size, cell wall integrity, stress responses, and cAMP/PKA and MAPK pathways [8 , 26 –39 ] Schizosaccharomyces pombe Cpc2 Stress responses, cell wall integrity, cell size, mitotic commitment, positive role in the general amino acid control response, cell cycle progression, and meiotic development [40 –43 ] Candida albicans Asc1 Growth, filamentation, adhesive growth, invasion, and virulence [44 , 45 ] Neurospora crassa cpc-2 Cross-pathway control, sexual reproduction, and the heterotrimeric G protein complex [46 –48 ] Aspergillus fumigatus CpcB Growth, conidiation, conidial germination, cell wall integrity, mycotoxin (gliotoxin) production, virulence, and antifungal drug resistance [49 –51 ] Aspergillus nidulans CpcB Growth, conidiation, conidial germination, sexual development, mycotoxin (sterigmatocystin) production, and cross-pathway control [50 , 52 ] Basidiomycetes Cryptococcus neoformans Gib2 Growth, virulence, a scaffolding adaptor protein, and a Gβ -like subunit of the cAMP/PKA pathway [53 –56 ] Ustilago maydis Rak1 Growth, cell wall integrity, cell fusion, filament formation, appressorium formation, virulence, and a ribosomal protein [53 , 57 ]
