Clinical Outcome and Prognostic Factors of Intensity-Modulated Radiotherapy for T4 Stage Nasopharyngeal Carcinoma

Table 2

Impact of prognostic factors on treatment according to univariate analysis (log-rank test).

Characteristics	LRFS		RRFS		DMFS		PFS		OS
Age (yrs)
≤44.5 yrs	89.4	0.743	96.0	0.895	62.4	0.418	63.9	0.876	63.5	0.813
>44.5 yrs	90.4		98.0		73.1		63.8		65.4
Gender
Male	90.0	0.334	96.2	0.331	62.4	0.418	63.9	0.876	63.0	0.493
Female	91.1		100.0		73.1		63.8		69.6
N stage
N0-1	91.9	0.807	100.0	0.110	75.8	0.339	75.9	0.272	79.4	0.087
N2-3	89.4		95.6		64.1		58.7		57.3
GTVnx (cc)
≤77.27	85.7	0.161	97.8	0.728	68.4	0.386	61.1	0.274	66.6	0.584
>77.27	95.4		96.1		70.3		67.0		62.4
GTVln (cc)
≤14.1	89.5	0.693	98.1	0.382	79.0	0.007	73.1	0.021	75.6	0.028
>14.1	91.3		95.7		56.1		55.0		53.0
Chemotherapy
Concurrent	90.8	0.788	97.0	0.431	71.6	0.214	68.6	0.149	70.2	0.250
Induction plus concurrent	89.3		97.0		58.8		54.1		52.6
IMRT replanning
No	83.8	0.023	96.2	0.853	65.9	0.743	56.7	0.302	62.6	0.646
Yes	97.7		97.9		71.1		69.4		67.2
Targeted therapy
No	87.8	0.308	97.6	0.339	69.6	0.532	64.7	0.941	62.6	0.841
Yes	96.2		100.0		61.5		61.5		70.0
Metastasis to RLN
No	90.9	0.941	100.0	0.468	91.7	0.075	83.3	0.122	91.7	0.034
Yes	90.1		96.6		64.3		61.4		61.0
Cervical nodal necrosis
No	92.1	0.181	97.0	0.660	73.7	0.065	71.0	0.064	71.6	0.112
Yes	86.3		96.7		57.3		52.0		51.6