BioMed Research International / 2016 / Article / Tab 1 / Clinical Study
Combination of Intra-Articular and Intraosseous Injections of Platelet Rich Plasma for Severe Knee Osteoarthritis: A Pilot Study Table 1 Demographic data and biological and clinical outcomes.
Demographic data Patients Total: Men: Women: Age: mean ± SD (range) OA III: OA IV: 13 9 (69.23) 4 (30.77) 62.23 ± 9.6 (47–75) 9 (69.23) 4 (30.77) Biological outcomes Baseline: mean ± SD One week after infiltration: mean ± SD MSC/μ L 7.98 ± 8.21 4.04 ± 5.36 0.019 CFU-F/mL 601.75 ± 312.30 139.19 ± 123.61 0.012 Clinical outcomes Baseline: mean ± SD Endpoint: mean ± SD δ : mean ± SD (% change)Improved patients: Patients with MCII [22 ]: KOOS pain 61.55 ± 14.11 74.60 ± 19.19 0.008 13.10 ± 14.89 (24.19 ± 40.07) 11 (84.62) 8 (61.53) KOOS symptoms 60.56 ± 17.35 71.70 ± 18.82 0.004 11.14 ± 11.34 (19.73 ± 25.42) 11 (84.62) 8 (61.53) KOOS ADL 68.44 ± 14.08 80.86 ± 15.58 0.022 12.45 ± 17.31 (23.25 ± 38.82) 11 (84.62) 8 (61.53) KOOS sport/rec. 29.23 ± 20.29 45.38 ± 22.40 0.017 11.78 ± 11.54 (76.94 ± 115.23) 10 (76.92) 7 (53.84) KOOS QOL 28.10 ± 19.75 39.28 ± 16.52 0.012 14.90 ± 22.03 (66.66 ± 72.64) 11 (84.62) 8 (61.53) VAS 6.77 ± 1.75 2.88 ± 2.48 <0.001 −3.88 ± 2.82 (−55.04 ± 38.21) 11 (84.62) 10 (76.92) Lequesne Index 8.69 ± 2.65 5.77 ± 3.49 0.008 −2.92 ± 3.35 (−31.18 ± 46.61) 10 (76.92)
OA: osteoarthritis; MSC: mesenchymal stem cells; CFU-F: cultures of colony-forming cells; VAS: visual analogue scale; KOOS: knee injury and osteoarthritis outcome score; ADL: function in daily living; sport/rec.: function in sport and recreation; QOL: quality of life; δ : difference from baseline. MCII: minimal clinically important improvement;
