The Use of Protein-Protein Interactions for the Analysis of the Associations between PM2.5 and Some Diseases

Table 3

Detailed information on 18 cardiovascular related genes with permutation FDR less than 0.05.

Disease gene	Maximum interaction score	Permutation FDR	Most related PM2.5 gene
DSP	999	0.009	JUP
PTGIS	977	0.011	PTGS2
EPHX1	995	0.012	CYP1A1
PPARG	999	0.017	PPARGC1A
OLR1	944	0.018	CCL2
PKP2	984	0.024	JUP
TCF4	994	0.028	ID1
NR3C2	953	0.029	SGK1
TCF7L2	997	0.029	JUP
ELN	993	0.033	FBN2
NEUROD1	939	0.035	ID2
F5	998	0.036	PROC
F13A1	970	0.037	FGG
BMPR2	999	0.039	BMP6
PNMT	952	0.04	EGR1
IL6	999	0.042	IL6ST
TNFSF4	859	0.042	STAT4
HNF1B	947	0.044	SOX9