Evidence for a “Pathogenic Triumvirate” in Congenital Hepatic Fibrosis in Autosomal Recessive Polycystic Kidney Disease

Figure 1

Characterization of hepatic cyst growth in PCK rats. (a) Liver/body weight ratio (as a percent of body weight) in Sprague-Dawley (SD) and polycystic kidney (PCK) rats was calculated from postnatal day (PND) 0 to PND 90. , significantly different than SD rats at the indicated time point (). (b) Cyst number was quantified in 200x, hematoxylin and eosin-stained images from PCK rats between PND 0 and PND 90. , significantly different than PND 0 (). (c) Pearson correlation of the relationship between liver weight and cyst number in PCK rats from PND 0 to PND 90. In all cases, –4 rats per genotype per time point.

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