Downregulation of ADAMTS8 by DNA Hypermethylation in Gastric Cancer and Its Clinical Significance

Table 3

Clinicopathological characteristics of gastric cancer samples and ADAMTS8 methylation.

Variable	Patients ()	ADAMTS8 methylation		value
		M (%)	U (%)
Age (years)
<65	40	25 (62.5)	15 (37.5)
≥65	26	15 (57.7)	11 (42.3)	0.365
Gender
Male	45	29 (64.4)	16 (35.6)
Female	21	11 (52.4)	10 (47.6)	0.219
Tumor differentiation
Well/moderate	33	23 (69.7)	10 (30.3)
Poor	33	17 (51.5)	16 (48.5)	0.614
Invasive depth
T1 + T2	22	10 (40.9)	12 (59.1)
T3 + T4	44	30 (70.5)	14 (29.5)	0.075
Tumor location
Upper + middle	13	8 (61.5)	5 (38.5)
Lower	53	32 (60.4)	21 (39.6)	0.478
Size (cm)
<3	28	15 (53.6)	13 (46.4)
≥3	38	25 (65.8)	13 (34.2)	0.621
Lymph node metastasis
No	20	7 (35.0)	13 (65.0)
Yes	46	33 (71.3)	13 (28.7)	0.005

. M: methylated and partially methylated cases; U: unmethylated cases; ADAMTS8: ADAM metallopeptidase with thrombospondin type 8 motif.