L-Malate’s Plasma and Excretion Profile in the Treatment of Moderate and Severe Hemorrhagic Shock in Rats

Figure 1

Effects of RS, MR7, MR13.6, and MR21 on the plasma malate concentration in severe and moderate hemorrhagic shock. Rats underwent moderate (a) or severe (b) hemorrhagic shock (dark gray: shock induction; light gray: shock phase; dark gray: resuscitation), were resuscitated with RS, MR7, MR13.6, or MR21, respectively, and were observed until the end of experiment or until the first animal of the RS-control group died. The values plotted are mean ± SEM of 6 individual experiments. Initial and final values were very close to the detection limit (except of initial value in MR21-treated group in severely shocked animals); hence SEM values in these cases are not shown.

(a)

(b)