L-Malate’s Plasma and Excretion Profile in the Treatment of Moderate and Severe Hemorrhagic Shock in Rats

Figure 3

Effects of RS, MR7, MR13.6, and MR21 on the excreted urine volume. Rats underwent moderate (a) or severe (b) hemorrhagic shock, were resuscitated with RS, MR7, MR13.6, or MR21, respectively, and were observed until the end of experiment. Urinary samples were collected immediately after catheter insertion and before shock induction ( = 0–30 min) and during shock induction ( = 30–60 min), resuscitation ( = 120–150 min), and the observation period ( = 180–240 min and = 240–300 min). The values plotted are mean ± SEM of 6 individual experiments. SEM values are not shown in the time interval = 180–240 min of severely shocked animals, because animals became anuric or died early, respectively.

(a)

(b)