The Occurrence of Genetic Alterations during the Progression of Breast Carcinoma

Figure 2

The distant-based and branching oncogenetic tree models for copy number alterations in 963 breast tumors. (a) In the distance-based oncogenetic tree, hidden or unknown events are represented as internal nodes. Leaves between the distances depend on the meaning of copy number changes with greater probability of cluster-related copy number variation. The root of the tree close to the left of the last point in the imbalance of genetic evolution occurred early. Interconnection path represents a high correlation between events, forming clusters of genetic balance. (b) In the branching oncogenetic tree, root represents the event with no alterations. The alterations genes include ErbB2, AKT2, KRAS, PIK3CA, PTEN, and CCND. The aberration of ErbB2 is potentially early event as it is close to the root and also the root of a new subtree.

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